Based at the Bio21 Institute, Melbourne Bioanalytics is an Australian ME/CFS research group of researchers and clinicians with decades of experience in ME/CFS. Their ME/CFS research focusses on the areas of metabolomics, genomics and microbiomics.
Metabolomics (which is the study of metabolites in cells) has become one of the key research areas in ME/CFS, and Melbourne Bioanalytics is one of the leading research groups in this area. In 2012, Melbourne Bioanalytics became the first in the world to publish a metabolomics study in ME/CFS. They expanded this study to a larger cohort in 2015, publishing the first findings which showed that people with ME/CFS make less energy from fast energy-producing sources (like glucose) and instead rely upon slower energy-producing sources (like amino acids).
This reduced metabolism has been referred to as hypometabolism, and these findings have since been replicated by several other well-respected international research groups, including Fluge and Mella’s team at Bergen University in Norway, and Davis’ team at Stanford University in the US. The replication of these findings is exciting, as it suggests that these groups are homing in on key aspects of the condition.
In 2009, Melbourne Bioanalytics were also the first in the world to publish findings of altered gut bacteria in ME/CFS patients, which has since also been found by groups in Belgium and Cornell University (USA). In 2016, they published a paper bringing together their findings of altered gut bacteria with the alterations they observed in energy metabolism. They found that gut bacteria changes in ME/CFS were associated with changes in break-down products of diet, which in turn were related to the altered energy metabolism in people with ME/CFS.
Melbourne Bioanalytics is now collaborating with international research groups to advance their ME/CFS research.
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